S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is,
however, expressed by other mesenchymal and epithelial tumors. Despite its low specificity,
S100 protein is valuable for the diagnosis of desmoplastic melanomas and peripheral nerve
sheath tumors, for which no specific marker is available. Sox10 is a neural crest transcription
factor crucial for specification, maturation, and maintenance of Schwann cells and
melanocytes. Anti-Sox10 antibody was applied to a variety of neural crest-derived tumors …